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Commonly stated damaging occasions linked with paroxetine overdosage consist of somnolence, coma, nausea, shake, tachycardia, confusion, throwing up, and lightheadedness. Various other notable indicators and also signs and symptoms noted with overdoses including paroxetine (alone or with other materials) consist of mydriasis, convulsions (including condition epilepticus), ventricular dysrhythmias (consisting of torsade de pointes), hypertension, aggressive responses, syncope, hypotension, amazement, bradycardia, dystonia, rhabdomyolysis, signs and symptoms of hepatic disorder (including hepatic failure, hepatic death, jaundice, liver disease, and also hepatic steatosis), serotonin syndrome, manic reactions, myoclonus, severe kidney failure, and also urinary system loyalty.

No certain remedies for paroxetine are known. Therapy should contain those basic steps used in the management of overdosage with any medications effective in the treatment of significant depressive ailment.

Ensure an appropriate air passage, oxygenation, and also air flow. Monitor heart rhythm as well as important signs. General symptomatic and also encouraging procedures are additionally recommended. Induction of emesis is not recommended. Because of the large volume of distribution of this medication, required diuresis, hemoperfusion, dialysis, or exchange transfusion are not likely to be of perk.

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A specific care entails clients which are taking or have just recently taken paroxetine which could consume too much amounts of a tricyclic antidepressant. In such a situation, buildup of the parent tricyclic and/or an energetic metabolite may enhance the opportunity of clinically considerable sequelae and also prolong the moment required for close clinical observation (view PRECAUTIONS: Drugs Metabolized by Cytochrome CYP2D6).

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